XRCC1 and DNA strand break repair

DNA Repair (Amst). 2003 Sep 18;2(9):955-69. doi: 10.1016/s1568-7864(03)00118-6.


DNA single-strand breaks can arise indirectly, as normal intermediates of DNA base excision repair, or directly from damage to deoxyribose. Because single-strand breaks are induced by endogenous reactive molecules such as reactive oxygen species, these lesions pose a continuous threat to genetic integrity. XRCC1 protein plays a major role in facilitating the repair of single-strand breaks in mammalian cells, via an ability to interact with multiple enzymatic components of repair reactions. Here, the protein-protein interactions facilitated by XRCC1, and the repair processes in which these interactions operate, are reviewed. Models for the repair of single-strand breaks during base excision repair and at direct breaks are presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CHO Cells
  • Cricetinae
  • DNA Damage*
  • DNA Repair*
  • DNA, Single-Stranded / genetics*
  • DNA-Binding Proteins / physiology*
  • Models, Biological
  • X-ray Repair Cross Complementing Protein 1


  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • X-ray Repair Cross Complementing Protein 1