Measurement of free fatty acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke

Brain Res. 2003 Sep 26;985(2):198-201. doi: 10.1016/s0006-8993(03)03044-0.


Free fatty acid (FFA) concentrations in cerebrospinal fluid (CSF) from patients with ischemic and hemorrhagic stroke (n=25) and in contemporary controls (n=73) were examined using HPLC. Concentrations of CSF FFAs from ischemic and hemorrhagic stroke patients obtained within 48 h of the insult were significantly greater than in control patients. Higher concentrations of polyunsaturated fatty acids (PUFAs) in CSF obtained within 48 h of insult were associated with significantly lower (P<0.05) admission Glasgow Coma Scale scores and worse outcome at the time of hospital discharge, using the Glasgow Outcome Scale (P<0.01).

Publication types

  • Comparative Study

MeSH terms

  • Chromatography, High Pressure Liquid
  • Disease Progression
  • Fatty Acids, Nonesterified / cerebrospinal fluid*
  • Fatty Acids, Nonesterified / classification
  • Glasgow Coma Scale
  • Humans
  • Ischemia / cerebrospinal fluid*
  • Statistics, Nonparametric
  • Subarachnoid Hemorrhage / cerebrospinal fluid*


  • Fatty Acids, Nonesterified