Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling

Trends Pharmacol Sci. 2003 Sep;24(9):486-92. doi: 10.1016/S0165-6147(03)00232-3.


Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca(2+) sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca(2+) homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Signaling / physiology*
  • Calcium-Binding Proteins / physiology
  • Dopamine / physiology*
  • Humans
  • Membrane Proteins / physiology
  • Mental Disorders / physiopathology
  • Neuronal Calcium-Sensor Proteins
  • Neuropeptides / physiology
  • Proteins / physiology*
  • Receptors, Dopamine / physiology*
  • Receptors, Dopamine D1 / physiology
  • Receptors, Dopamine D2 / physiology


  • Calcium-Binding Proteins
  • Membrane Proteins
  • Neuronal Calcium-Sensor Proteins
  • Neuropeptides
  • Proteins
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • calcyon
  • frequenin calcium sensor proteins
  • Dopamine