Impact of reproductive history on in vitro fertilization and intracytoplasmic sperm injection outcome: evidence from the German IVF Registry

Fertil Steril. 2003 Sep;80(3):508-16. doi: 10.1016/s0015-0282(03)00760-x.


Objective: To evaluate the effect of reproductive history on the outcome of different procedures in assisted reproductive technologies (ART) comparing IVF, ICSI, and cryopreserved embryo transfer (CPE).

Design: Prospective registration of ART cycles and their outcomes.

Setting: One hundred three reproductive programs in Germany.

Patient(s): Women undergoing 174,909 ART procedures from January 1998 through December 2000.

Intervention(s): Data analysis of reproductive history collected by the German IVF Registry; multiple logistic regression modeling of success rates.

Main outcome measure(s): Effect of type of conception and outcome of previous pregnancies, duration of infertility, female's age, and type of ART on clinical pregnancy rate per retrieval. Odds ratios with 95% CIs are reported.

Result(s): More than one previous pregnancy was negatively correlated with outcome of IVF, ICSI, or CPE. This association disappeared when female age was restricted to a maximum of 35 years. A previous pregnancy achieved by spontaneous conception had less impact on outcome of IVF, ICSI or CPE outcome than did a previous assisted conception. Previous live births and miscarriages demonstrated a statistically significant increase compared with ectopic pregnancies and induced abortions.

Conclusion(s): Reproductive history must be considered when counseling subfertile couples. Female age, method of conception, and previous pregnancy outcome have a significant effect on IVF, ICSI, and CPE outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Spontaneous
  • Adolescent
  • Adult
  • Cryopreservation
  • Embryo Transfer
  • Female
  • Fertilization in Vitro*
  • Germany
  • Gravidity
  • Humans
  • Infertility / physiopathology
  • Infertility / therapy
  • Medical Records*
  • Middle Aged
  • Oocytes
  • Parity
  • Pregnancy
  • Pregnancy Rate
  • Registries
  • Reproduction*
  • Sperm Injections, Intracytoplasmic*
  • Time Factors
  • Tissue and Organ Harvesting