Abstract
We demonstrate here for the first time that the endogenous cyclopentenone prostaglandin 15-deoxy-Delta12,14-prostaglandin J2 (15d-prostaglandin J2) reduces the liver injury (rise in serum transaminases) caused by severe endotoxaemia (6 mg/kg Escherichia coli endotoxin i.v. for 6 h) in the anaesthetised rat. The protection of the liver afforded by this potent agonist of PPAR-gamma was not secondary to a haemodynamic effect. Thus, 15d-prostaglandin J2 and other PPAR-gamma agonists may be useful in the therapy of septic shock.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Aspartate Aminotransferases / blood
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Endotoxins
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Escherichia coli
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Ligands
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Liver Diseases / etiology
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Liver Diseases / metabolism
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Liver Diseases / prevention & control*
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Male
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Prostaglandin D2 / analogs & derivatives
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Prostaglandin D2 / pharmacology*
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Rats
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Rats, Wistar
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Shock, Septic / chemically induced
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Shock, Septic / complications*
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Transcription Factors / metabolism*
Substances
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15-deoxy-delta(12,14)-prostaglandin J2
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Anti-Inflammatory Agents
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Endotoxins
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors
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endotoxin, Escherichia coli
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Aspartate Aminotransferases
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Alanine Transaminase
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Prostaglandin D2