The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock

Eur J Pharmacol. 2003 Aug 29;476(3):257-8. doi: 10.1016/s0014-2999(03)02179-4.

Abstract

We demonstrate here for the first time that the endogenous cyclopentenone prostaglandin 15-deoxy-Delta12,14-prostaglandin J2 (15d-prostaglandin J2) reduces the liver injury (rise in serum transaminases) caused by severe endotoxaemia (6 mg/kg Escherichia coli endotoxin i.v. for 6 h) in the anaesthetised rat. The protection of the liver afforded by this potent agonist of PPAR-gamma was not secondary to a haemodynamic effect. Thus, 15d-prostaglandin J2 and other PPAR-gamma agonists may be useful in the therapy of septic shock.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Aspartate Aminotransferases / blood
  • Endotoxins
  • Escherichia coli
  • Ligands
  • Liver Diseases / etiology
  • Liver Diseases / metabolism
  • Liver Diseases / prevention & control*
  • Male
  • Prostaglandin D2 / analogs & derivatives
  • Prostaglandin D2 / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Shock, Septic / chemically induced
  • Shock, Septic / complications*
  • Transcription Factors / metabolism*

Substances

  • 15-deoxy-delta(12,14)-prostaglandin J2
  • Anti-Inflammatory Agents
  • Endotoxins
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • endotoxin, Escherichia coli
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Prostaglandin D2