Beta A4 amyloid protein and its precursor in Alzheimer's disease

Pharmacol Ther. 1992;56(1):97-117. doi: 10.1016/0163-7258(92)90039-3.


The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Amino Acid Sequence
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / physiology*
  • Amyloid beta-Protein Precursor / physiology
  • Animals
  • Humans
  • Molecular Sequence Data


  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor