High [18F] 2-fluoro-2-deoxy-D-glucose (FDG) uptake of adrenocortical adenoma showing subclinical Cushing's syndrome

Ann Nucl Med. 2003 Jul;17(5):403-6. doi: 10.1007/BF03006609.

Abstract

A 48-year-old woman with left adrenal tumor, which showed increased uptake of [18F] 2-fluoro-2-deoxy-D-glucose (FDG) was presented. Her adrenal tumor was incidentally discovered, although she had no remarkable illness, and her blood pressure was normal. Hormonal examination including dexamethason suppression test and diurnal variation in serum cortisol level confirmed preclinical Cushing's syndrome. CT, MRI and 131I-adosterol scintigraphy showed findings consistent with adenoma. FDG-PET revealed that tumor had standardized uptake value of 4.8, which was higher than usual benign tumors. Histological diagnosis of the resected adrenal tumor was adrenocortical adenoma without evidence of malignancy. Although the current literature showed that adenomas in general did not exhibit increased FDG uptake, adenoma in the present case with subclinical Cushing's syndrome showed intense uptake of FDG, suggesting FDG-PET could evaluate hormonal function of an adrenocortical adenoma in a completely asymptomatic normocortisolism patient.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Neoplasms / blood
  • Adrenal Cortex Neoplasms / diagnosis
  • Adrenal Cortex Neoplasms / diagnostic imaging*
  • Adrenal Cortex Neoplasms / metabolism
  • Adrenocortical Adenoma / blood
  • Adrenocortical Adenoma / diagnosis
  • Adrenocortical Adenoma / diagnostic imaging*
  • Adrenocortical Adenoma / metabolism
  • Adrenocorticotropic Hormone / blood
  • Cushing Syndrome / blood
  • Cushing Syndrome / diagnosis
  • Cushing Syndrome / diagnostic imaging*
  • Cushing Syndrome / metabolism
  • Female
  • Fluorodeoxyglucose F18* / pharmacokinetics
  • Humans
  • Hydrocortisone / blood
  • Incidental Findings
  • Middle Aged
  • Radionuclide Imaging
  • Radiopharmaceuticals / pharmacokinetics

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Adrenocorticotropic Hormone
  • Hydrocortisone