A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?

Blood Cells Mol Dis. Sep-Oct 2003;31(2):262-7. doi: 10.1016/s1079-9796(03)00133-5.

Abstract

The aim of this new meta-analysis (to the end of 2002) is to compile the Y allele frequencies of the C282Y mutation of hereditary hemochromatosis (HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of C282Y frequencies in Europe was constructed. The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia.

Publication types

  • Meta-Analysis

MeSH terms

  • Cysteine / genetics
  • Europe / ethnology
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetics, Population
  • Genotype
  • Hemochromatosis / ethnology
  • Hemochromatosis / genetics*
  • Hemochromatosis Protein
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Point Mutation*
  • Tyrosine / genetics

Substances

  • HFE protein, human
  • Hemochromatosis Protein
  • Histocompatibility Antigens Class I
  • Membrane Proteins
  • Tyrosine
  • Cysteine