Associations between plasma natriuretic peptide levels, symptoms, and left ventricular function in patients with chronic aortic regurgitation

Am J Cardiol. 2003 Sep 15;92(6):755-8. doi: 10.1016/s0002-9149(03)00849-x.


In 40 patients with chronic moderate to severe aortic regurgitation, brain natriuretic peptide, N-brain natriuretic peptide, and atrial natriuretic peptide were higher in symptomatic patients compared with asymptomatic patients after adjustment for age, gender, and ejection fraction, but each natriuretic peptide correlated weakly with echocardiographic measures of left ventricular size and function. In patients with chronic aortic regurgitation, measurement of natriuretic peptide levels may provide information on left ventricular function in addition to echocardiography.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aortic Valve Insufficiency / blood*
  • Aortic Valve Insufficiency / complications*
  • Aortic Valve Insufficiency / diagnostic imaging
  • Atrial Natriuretic Factor / blood*
  • Chronic Disease
  • Echocardiography
  • Female
  • Humans
  • Male
  • Natriuretic Peptide, Brain / blood*
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Stroke Volume
  • Ventricular Dysfunction, Left / blood*
  • Ventricular Dysfunction, Left / diagnostic imaging
  • Ventricular Dysfunction, Left / etiology*


  • Natriuretic Peptide, Brain
  • Atrial Natriuretic Factor