[Pragmatic clinical trials: an option in the construction of health-related evidence]

Cad Saude Publica. 2003 Jul-Aug;19(4):1189-93. doi: 10.1590/s0102-311x2003000400039. Epub 2003 Sep 8.
[Article in Portuguese]


The authors present and discuss the potential of pragmatic clinical trials as an alternative to both explanatory trials and observational studies to support the use of therapeutic interventions with good evidence. They argue that this strategy, when properly applied, can be a powerful tool to obtain unbiased measures of effectiveness, with simpler logistics and lower costs than in current clinical trials.

Publication types

  • English Abstract

MeSH terms

  • Clinical Trials as Topic*
  • Epidemiologic Studies*
  • Evidence-Based Medicine*
  • Randomized Controlled Trials as Topic