Co-stimulatory Members of the TNFR Family: Keys to Effective T-cell Immunity?

Nat Rev Immunol. 2003 Aug;3(8):609-20. doi: 10.1038/nri1148.

Abstract

Interactions between co-stimulatory ligands and their receptors are crucial for the activation of T cells, the prevention of tolerance and the development of T-cell immunity. It is now evident that members of the immunoglobulin-like CD28-B7 co-stimulatory family cannot fully account for an effective long-lasting T-cell response or the generation of memory T cells. Several members of the tumour-necrosis factor receptor (TNFR) superfamily--OX40, 4-1BB, CD27, CD30 and HVEM (herpes-virus entry mediator)--are poised to deliver co-stimulatory signals both early and late after encounter with antigen. The roles of these molecules in initiating and sustaining the T-cell response and in promoting long-lived immunity are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD
  • Antigens, Differentiation / immunology
  • Humans
  • Ki-1 Antigen / immunology
  • Lymphocyte Activation / immunology*
  • Mice
  • Receptors, Nerve Growth Factor / immunology
  • Receptors, Tumor Necrosis Factor / immunology*
  • Receptors, Tumor Necrosis Factor, Member 14
  • Receptors, Virus / immunology
  • Signal Transduction / immunology
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / immunology
  • Tumor Necrosis Factor Receptor Superfamily, Member 9

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Ki-1 Antigen
  • OX40Ig
  • Receptors, Nerve Growth Factor
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Member 14
  • Receptors, Virus
  • TNFRSF14 protein, human
  • TNFRSF9 protein, human
  • Tnfrsf14 protein, mouse
  • Tnfrsf9 protein, mouse
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  • Tumor Necrosis Factor Receptor Superfamily, Member 9