Ebola virus: from discovery to vaccine

Nat Rev Immunol. 2003 Aug;3(8):677-85. doi: 10.1038/nri1154.


Ebola virus, being highly pathogenic for humans and non-human primates and the subject of former weapons programmes, is now one of the most feared pathogens worldwide. In addition, the lack of pre- and post-exposure interventions makes the development of rapid diagnostics, new antiviral agents and protective vaccines a priority for many nations. Further insight into the ecology, immunology and pathogenesis of Ebola virus will promote the delivery of these urgently required tools.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Ebolavirus / immunology*
  • Hemorrhagic Fever, Ebola / epidemiology
  • Hemorrhagic Fever, Ebola / immunology*
  • Hemorrhagic Fever, Ebola / prevention & control
  • Humans
  • Macaca fascicularis
  • Vaccines, Attenuated / immunology
  • Viral Vaccines / immunology*


  • Vaccines, Attenuated
  • Viral Vaccines