Psychomotor development in children exposed in utero to benzodiazepines, antidepressants, neuroleptics, and anti-epileptics

Eur J Epidemiol. 2003;18(8):769-71. doi: 10.1023/a:1025306304635.


We did a follow-up study based upon a regional prescription register in Denmark. We identified all 435 women who in the period 1991-1996 had redeemed a prescription for CNS drugs during pregnancy. Among the rest of the pregnant women we randomly selected 1304 women who also had given birth to a child in the same region and period. We looked up the local health nurses Boel test results which were available for about 80%. Any abnormal test result was seen much more frequently among exposed (16%) than for not exposed (4%). The study has several limitations but raises concern that should be addressed in other and better designed studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anticonvulsants / adverse effects*
  • Benzodiazepines / adverse effects*
  • Case-Control Studies
  • Child Development / drug effects*
  • Contraindications
  • Denmark / epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Logistic Models
  • Maternal Exposure / adverse effects
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Psychomotor Disorders / chemically induced*
  • Psychomotor Disorders / diagnosis
  • Psychomotor Disorders / epidemiology
  • Psychotropic Drugs / adverse effects*
  • Registries
  • Risk Factors


  • Anticonvulsants
  • Psychotropic Drugs
  • Benzodiazepines