Abstract
Cell cultures obtained from human uveal tumours have been used as experimental model to study the lethal effect consecutive to the neutron capture reaction on boron incorporated into cells as borophenylalanine. An irradiation with a neutron fluence of 6 x 10(9) n cm-2 reduced the number of viable cells by about 30%.
MeSH terms
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Boron Compounds / metabolism
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Boron Neutron Capture Therapy
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Cell Death / radiation effects
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Culture Media
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Humans
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Melanoma / metabolism*
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Melanoma / pathology
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Melanoma / radiotherapy*
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Phenylalanine / metabolism
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Tumor Cells, Cultured / radiation effects
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Uveal Neoplasms / metabolism*
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Uveal Neoplasms / pathology
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Uveal Neoplasms / radiotherapy*
Substances
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Boron Compounds
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Culture Media
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Phenylalanine