15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product?

J Clin Invest. 2003 Sep;112(6):828-30. doi: 10.1172/JCI19796.


15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) affects gene transcription by activating PPARgamma and by covalent addition to transcription factors and signaling molecules, However, it is not known whether the high concentrations of 15d-PGJ2 required for these responses are consistent with physiological levels. A new study suggests that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule.

Publication types

  • Comment

MeSH terms

  • Animals
  • Immunologic Factors / metabolism*
  • Ligands
  • Molecular Structure
  • Prostaglandin D2 / analogs & derivatives
  • Prostaglandin D2 / metabolism*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Prostaglandin / metabolism
  • Signal Transduction / physiology
  • Transcription Factors / metabolism*


  • 15-deoxy-delta(12,14)-prostaglandin J2
  • Immunologic Factors
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Prostaglandin
  • Transcription Factors
  • Prostaglandin D2