Transcriptional repression by methylation of CpG

J Cell Sci Suppl. 1992;16:9-14. doi: 10.1242/jcs.1992.supplement_16.2.

Abstract

Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA / metabolism
  • DNA-Binding Proteins* / metabolism
  • Dinucleoside Phosphates / metabolism
  • Methylation
  • Mice
  • Repressor Proteins
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • Dinucleoside Phosphates
  • Repressor Proteins
  • DNA