A total of 204 blood samples were collected from healthy, unrelated Adi-Dravidars of Chengalput District, Tamil, India. These samples were screened for ABO and RH blood groups using the respective antisera. CP and ALB serum protein electrophoretic phenotypes were assessed. The chi 2 analysis for Hardy-Weinberg equilibrium revealed that the population fits in panmictic equilibrium. The results were compared with the findings reported for other populations of Southern India.