Very late activation-3 integrin is the dominant beta 1-integrin on the glomerular capillary wall: an immunofluorescence study in nephrotic syndrome

Nephron. 1992;62(4):382-8. doi: 10.1159/000187085.


The expression of alpha 2; alpha 3; alpha 5; alpha 6-subunits of the beta 1 [very late activation (VLA)] integrin family was studied in kidney specimens using an immunofluorescent technique. 6 specimens from normal kidney were compared with 10 specimens from patients affected by various glomerulopathies [minimal change nephropathy (MCN), membranous nephropathy (MN) and systemic lupus erythematosus nephritis (SLEN)]. On normal glomeruli, alpha 3 was the dominant integrin, being mainly present on podocytes and showing a linear fluorescent pattern codistributed with laminin. In MCN and SLEN, alpha 3 presented a normal pattern. In MN, alpha 3 revealed a trabecular picture on thickened glomerular basement membranes. Moreover, in stage-III MN, a segmental loss of alpha 3-integrin was detected. In our opinion, VLA-3 may offer an interesting approach to the study of the relationships between podocytes and their substrate.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Monoclonal / immunology
  • Biopsy
  • Capillaries / metabolism*
  • Female
  • Fluorescent Antibody Technique
  • Glomerulonephritis, Membranous / metabolism
  • Humans
  • Kidney Glomerulus / blood supply
  • Kidney Glomerulus / metabolism*
  • Lupus Erythematosus, Systemic / metabolism
  • Male
  • Nephrosis, Lipoid / metabolism
  • Nephrotic Syndrome / metabolism*
  • Receptors, Very Late Antigen / metabolism*


  • Antibodies, Monoclonal
  • Receptors, Very Late Antigen