[Evaluation of the effectiveness of cisapride in the treatment of gastroesophageal reflux]

Minerva Pediatr. 1992 Dec;44(12):613-6.
[Article in Italian]

Abstract

To evaluate the effectiveness of administration of oral cisapride in patients with gastro-esophageal reflux, we studied 25 children, aged 1 month-7 years (mean 16.2 months) affected with GER. At the time of diagnosis and 8 weeks after treatment, patients were clinically evaluated and underwent a 24-hour continuous esophageal pH-monitoring. After treatment a complete regression of symptoms was observed in 20/25 patients. Moreover we recorded a significant reduction in the percentage of reflux time (p < 0.0001) and in the Jolley score (p < 0.0001), a very accurate scoring system to evaluate the pH-metric tracing, after treatment. It is concluded that cisapride is a useful agent both for the relief of symptoms and for the improvement of pH-metric parameters in children with GER disease.

Publication types

  • English Abstract

MeSH terms

  • Child
  • Child, Preschool
  • Cisapride
  • Evaluation Studies as Topic
  • Female
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Piperidines / therapeutic use*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*

Substances

  • Piperidines
  • Serotonin Uptake Inhibitors
  • Cisapride