The human PAX6 gene is mutated in two patients with aniridia

Nat Genet. 1992 Aug;1(5):328-32. doi: 10.1038/ng0892-328.


Aniridia is an inherited ocular disorder of variable expressivity characterized by iris hypoplasia. A candidate aniridia gene, AN, which is the human homologue of the mouse Pax-6 gene, has recently been isolated by positional cloning from the WAGR region of 11p13. Here we describe mutations in this gene in two cases of sporadic aniridia, one detected at the DNA level and one at the RNA level, both of which are predicted to affect protein function. Mutations in Pax-6 have been described previously in Small eye, the proposed mouse model for aniridia. We present new phenotypic evidence for the validity of this mouse model.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aniridia / genetics*
  • Base Sequence
  • Cell Line
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • DNA / genetics
  • DNA / isolation & purification
  • Exons
  • Humans
  • Mice
  • Molecular Sequence Data
  • Mutation*
  • Oligodeoxyribonucleotides
  • Phenotype
  • Polymerase Chain Reaction / methods
  • Sequence Deletion


  • Oligodeoxyribonucleotides
  • DNA