Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease

Ophthalmology. 1992 Apr;99(4):594-9. doi: 10.1016/s0161-6420(92)31950-5.


Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU). Follow-up for eyes in which intraocular pressure was controlled ranged from 6 to 53 months (mean, 34 months; median, 35 months). Fifteen of 21 eyes (71%) had controlled intraocular pressure (21 mmHg or less). Control was achieved in 9 of 10 (90%) phakic eyes and in 6 of 11 (55%) aphakic or pseudophakic eyes with or without glaucoma medication. Four of six filter failures had a second filtering procedure with 5-FU, and of these four procedures, three were successful. Cataract progression occurred in 9 of 10 phakic eyes, leading to cataract surgery in 7 eyes. Other complications included corneal epithelial defects in 13 eyes, bleb leaks in 3 eyes, choroidal effusions in 13 eyes, 1 choroidal hemorrhage, 1 serous retinal detachment and macular retinal pigment epithelial disturbance associated with hypotony and choroidal effusion. Filtering surgery with postoperative subconjunctival 5-FU can successfully control intraocular pressure in eyes with ocular inflammatory disease.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cataract Extraction
  • Conjunctiva / drug effects
  • Female
  • Fluorouracil / therapeutic use*
  • Follow-Up Studies
  • Glaucoma / surgery*
  • Humans
  • Injections
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Postoperative Complications / prevention & control
  • Retrospective Studies
  • Trabeculectomy*
  • Uveitis / surgery*
  • Visual Acuity


  • Fluorouracil