[Treatment of intestinal metaplasia and atypical hyperplasia of gastric mucosa with xiao wei yan powder]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Oct;12(10):602-3, 580.
[Article in Chinese]


138 cases of intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH) of the gastric mucosa of chronic gastritis treated with Xiao Wei Yan Powder (XWYP) were reported. The diagnoses were based on the pathological examination of gastric antrum biopsy specimens. The cases were randomly divided into treated group and control group. The XWYP contained Smilax glabrae, Hedyotis diffusae, Taraxacum mongolicum, Caesalpinia sappan, Paeonia alba, Cyperus rotundus, Bletilla striata, Glycyrrhiza uralensis etc., and was prepared in powder form, taken orally 5-7g tid. After 2-4 months of administration, gastroscopic and pathological examinations were repeated.

Results: In treated group, the total effective rate of IM was 91.3% and that of the AH was 92.16%, while in control group, they were 21.3% and 14.46% respectively (P < 0.01). It denoated that XWYP had marked therapeutic effects for IM and AH. The animal experiments revealed no toxic effect, so safety guarantee was provided for its clinical application.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Gastric Mucosa / pathology*
  • Gastritis / drug therapy
  • Gastritis / pathology
  • Gastritis, Atrophic / drug therapy*
  • Gastritis, Atrophic / pathology*
  • Humans
  • Male
  • Metaplasia
  • Middle Aged
  • Precancerous Conditions / drug therapy
  • Precancerous Conditions / pathology
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / pathology


  • Drugs, Chinese Herbal