Molecular evolution of the human interleukin-8 receptor gene cluster

Nat Genet. 1992 Sep;2(1):31-6. doi: 10.1038/ng0992-31.


Interleukin-8 (IL-8) is the prototype for a family of at least eight neutrophil chemoattractants whose genes map to human chromosome 4q13-q21. Two human IL-8 receptors, IL8RA and IL8RB, are known from cDNA cloning; IL8RA is a promiscuous receptor for at least two other related ligands, GRO alpha and NAP-2. We now report cloning of the genes for IL8RA, IL8RB and a recently inactivated pseudogene of receptor A (IL8RAP). These form a cluster of only three genes in the superfamily of G protein-coupled receptors (GPCRs) and map to 2q34-q35. The coevolutionary diversity displayed by the IL-8 ligand-receptor complex--ligand promiscuity for IL-8, receptor promiscuity for IL8RA, gene duplication for both ligands and receptors and gene extinction in the case of IL8RAP--is unprecedented for the GPCR superfamily.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Biological Evolution*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4
  • DNA / genetics
  • Humans
  • Molecular Sequence Data
  • Multigene Family*
  • Polymerase Chain Reaction
  • Pseudogenes
  • Receptors, Immunologic / genetics*
  • Receptors, Interleukin-8A
  • Sequence Homology, Amino Acid


  • Receptors, Immunologic
  • Receptors, Interleukin-8A
  • DNA

Associated data

  • GENBANK/M98335