Genetic dissection of autoimmune type I diabetes in the BB rat

Nat Genet. 1992 Sep;2(1):56-60. doi: 10.1038/ng0992-56.


The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Crosses, Genetic
  • DNA / genetics
  • Diabetes Mellitus, Type 1 / genetics*
  • Female
  • Genes, Recessive
  • Genetic Linkage
  • Genetic Markers
  • Lymphopenia / genetics
  • Major Histocompatibility Complex
  • Male
  • Molecular Sequence Data
  • Neuropeptide Y / genetics
  • Rats
  • Rats, Inbred BB
  • Rats, Inbred F344
  • Rats, Inbred Lew
  • T-Lymphocytes


  • Genetic Markers
  • Neuropeptide Y
  • DNA