Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

Nat Genet. 1992 Oct;2(2):128-31. doi: 10.1038/ng1092-128.


A predisposing gene for breast and ovarian cancer has recently been mapped to chromosome 17q12-21. If this gene is a tumour suppressor gene, allele losses would be expected in the tumours of affected family members and the losses should affect the wild-type chromosome, reflecting the need for inactivation of the wild-type allele at the predisposing locus. In four multiple case breast-ovarian cancer families, we have found that in each of nine tumours which showed allele losses, the losses were from the wild-type chromosome. This suggests that the putative 'breast-ovarian' cancer gene is indeed a tumour suppressor gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Breast Neoplasms / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 17*
  • Female
  • Gene Deletion
  • Genes, Tumor Suppressor
  • Humans
  • Male
  • Ovarian Neoplasms / genetics*
  • Pedigree