Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

C Van Broeckhoven; H Backhovens; M Cruts; G De Winter; M Bruyland; P Cras; J J Martin

doi:10.1038/ng1292-335

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

Nat Genet. 1992 Dec;2(4):335-9. doi: 10.1038/ng1292-335.

Authors

C Van Broeckhoven¹, H Backhovens, M Cruts, G De Winter, M Bruyland, P Cras, J J Martin

Affiliation

¹ Laboratory of Neurogenetics, Born Bunge Foundation, University of Antwerp, Belgium.

PMID: 1303290
DOI: 10.1038/ng1292-335

Abstract

Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the beta-amyloid protein precursor gene located in 21q21.3 have indicated that early-onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)n dinucleotide repeat polymorphism at locus D14S43 in 14q24.3 (Zmax = 13.25 at theta = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between D14S42 and D14S53, flanking D14S43 on both sides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alzheimer Disease / genetics*
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 14*
Chromosomes, Human, Pair 21
DNA / genetics
Female
Genetic Markers
Humans
Lod Score
Male
Pedigree
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid

Substances

Genetic Markers
DNA