Abstract
The potassium-containing salt substitute sanasol was examined for its effects on blood pressure and renal function in normo- and hypertensive rats, as well as on the edematous syndrome in circulatory insufficiency. The antihypertensive and occasional antiedematous effects of sanasol resulted in unfavorable changes in electrolyte balance. Sanasol was found to be ineffective in experimental renal failure.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Blood Circulation / drug effects*
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Blood Pressure / drug effects*
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Drug Evaluation, Preclinical
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Homeostasis / drug effects*
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Hypertension / drug therapy
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Hypertension / physiopathology
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Hypertension, Renovascular / drug therapy
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Hypertension, Renovascular / physiopathology
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Kidney / drug effects*
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Kidney / physiopathology
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Mice
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Potassium / pharmacology*
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Potassium / therapeutic use
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Rats
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Renal Insufficiency / drug therapy
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Renal Insufficiency / physiopathology
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Stress, Physiological / drug therapy
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Stress, Physiological / physiopathology
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Water-Electrolyte Balance / drug effects*