Prospective study of Lewis antigen alterations in the gastric precancerous process

Cancer Epidemiol Biomarkers Prev. 1992 Mar-Apr;1(3):199-205.

Abstract

A prospective study with two gastric biopsies taken several years apart was carried out in 117 subjects with intestinal metaplasia who are of the Lewis(a-b+) phenotype. They are residents of a rural Andean region in Colombia displaying very high rates of gastric cancer. The anomalous expression of Lewis(a) antigens in the metaplastic epithelium carried a significantly increased risk of colonic metaplasia and dysplasia. Such risk was much higher when the simultaneous expression of sulfomucins and Lewis(a) antigen was observed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / genetics*
  • Biopsy
  • Colombia / epidemiology
  • Female
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Intestinal Diseases / epidemiology
  • Intestinal Diseases / genetics
  • Intestinal Diseases / pathology*
  • Lewis Blood Group Antigens / genetics*
  • Male
  • Metaplasia
  • Middle Aged
  • Mucins / genetics
  • Phenotype
  • Precancerous Conditions / epidemiology
  • Precancerous Conditions / genetics
  • Precancerous Conditions / pathology*
  • Prospective Studies
  • Risk Factors
  • Rural Population
  • Sensitivity and Specificity
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / pathology*

Substances

  • Biomarkers, Tumor
  • Lewis Blood Group Antigens
  • Mucins
  • sulfomucin