[A study of the antiarrhythmic mechanism of berberine on delayed activation potassium current by voltage clamp]

Zhonghua Xin Xue Guan Bing Za Zhi. 1992 Oct;20(5):310-2, 325.
[Article in Chinese]


The effects of berberine (0.1-10 mg/L) on delayed activation potassium current (iK) of canine Purkinje fibers were studied with two-microelectrode voltage clamp technique. Berberine (Ber) significantly reduced the amplitude of iK in concentration-dependent manner. When perfused with 10 mg/L Ber, the amplitude of tail current of the Purkinje fibers decreased immediately and the inhibition rate was 73.6 +/- 4.5% (n = 9, P < 0.001). The inhibition effect of berberine on iK may explain its prolongation effect on action potential duration and its antiarrhythmic action.

Publication types

  • English Abstract

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Anti-Arrhythmia Agents / pharmacology*
  • Berberine / pharmacology*
  • Dogs
  • Heart / physiology
  • In Vitro Techniques
  • Potassium Channels / drug effects*
  • Purkinje Fibers / drug effects


  • Anti-Arrhythmia Agents
  • Potassium Channels
  • Berberine