Recombinant versus plasma-derived hepatitis B vaccine: comparison of immunogenicity in medical students

Vaccine. 1992;10(11):740-1. doi: 10.1016/0264-410x(92)90507-g.


A group of 92 medical students were immunized with a commercial recombinant hepatitis B vaccine (Engerix B). Antibody responses were determined and compared with those to plasma-derived Pasteur vaccine, obtained in 1986. Antibody concentrations were significantly higher in the group given recombinant vaccine, therefore this vaccine has superior immunogenicity and probably confers extended duration of protection.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Female
  • Hepatitis B Antibodies / biosynthesis*
  • Hepatitis B Antibodies / blood
  • Hepatitis B Vaccines / blood*
  • Hepatitis B Vaccines / immunology*
  • Humans
  • Injections, Intramuscular
  • Male
  • Students, Medical
  • Vaccines, Synthetic / immunology*


  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Vaccines, Synthetic