Head circumference of children with Down syndrome (0-36 months)

Am J Med Genet. 1992 Jan 1;42(1):61-7. doi: 10.1002/ajmg.1320420114.


This study provides statistically appropriate head circumference reference curves for males and females with Down syndrome (DS) from birth to 36 months of age. A total of 239 males and 182 females from five study populations, yielding a combination of cross-sectional and longitudinal data, were used for the analysis. The method of least squares was used to test the fit of the growth model y = a+bx+c[log(x + 1)], where x is age in months. These standardized curves should provide information of value in the medical, physical, and developmental management of children with DS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biometry
  • Cephalometry
  • Child, Preschool
  • Down Syndrome / pathology*
  • Female
  • Head / pathology*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Reference Values