Electron microscopic study of the cases of minimal change nephrotic syndrome with mesangial IgA deposition

Yonsei Med J. 1992 Dec;33(4):351-6. doi: 10.3349/ymj.1992.33.4.351.


Twenty-five cases of minimal change nephrotic syndrome(minimal change disease, MCD) with mesangial IgA deposition were evaluated electron microscopically. The thickness of the glomerular basement membrane(GBM) was 3875 +/- 1271 A and 3056 +/- 1201 A in adults and children, respectively. Alteration of the GBM was noted in 3 adults and eight children: splitting in 4, focal thinning in one, widening of the lamina rara interna in 10, and widening of the lamina rara externa in 4 cases. Minimal mesangial electron dense deposits were found in all but one adult, and an increase of the mesangial matrix and minimal mesangial proliferation were observed in 8 and 6 cases, respectively. Electron microscopic findings show representative findings of MCD in our cases. A relationship between the GBM alterations in these cases and frequent association of hematuria is suggested and discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Glomerular Mesangium / metabolism*
  • Humans
  • Immunoglobulin A / metabolism*
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Nephrosis, Lipoid / metabolism*
  • Nephrosis, Lipoid / pathology*


  • Immunoglobulin A