Hepatocellular carcinoma associated with arteriohepatic dysplasia in a 4-year-old girl

Med Pediatr Oncol. 1992;20(1):78-83. doi: 10.1002/mpo.2950200118.


Hepatocellular carcinoma and obliterated hepatic bile duct were found at postmortem examination in a 4-year-old girl with arteriohepatic dysplasia (Alagille's syndrome). AFP level was extremely high. Liver cirrhosis was present on percutaneous needle biopsy 9 months before she succumbed in progressive liver failure. Episodes of repeated gastrointestinal, life-threatening hemorrhages occurred during the last 6 months of her life. Histopathologic findings of the eyes were documented at autopsy.

Publication types

  • Case Reports

MeSH terms

  • Alagille Syndrome / complications*
  • Alagille Syndrome / diagnosis
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / etiology*
  • Child, Preschool
  • Eye / pathology
  • Female
  • Humans
  • Liver / pathology
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / etiology*
  • Liver Neoplasms / pathology