Nucleotide sequence analysis of a homologue of herpes simplex virus type 1 gene US9 found in the genome of simian herpes B virus

J Gen Virol. 1992 Jan;73 ( Pt 1):195-9. doi: 10.1099/0022-1317-73-1-195.

Abstract

The 10K gene of simian herpes B virus (SHBV) has been located and the nucleotide sequence determined. Its relationship to homologous genes in other herpes-viruses has been examined. The SHBV 10K gene exhibits a closer relationship to its homologue in HSV-1 than to those in the other viruses studied. Nucleotide sequence identity of 61% was found between the HSV-1 and SHBV 10K genes, and 57% identity was found between the corresponding predicted protein sequences. A comparison of the amino acid sequences of the herpesvirus 10K proteins has revealed a number of conserved features. These are examined in relation to possible functions of the 10K proteins. Implications for evolutionary relationships between SHBV and other herpesviruses are discussed.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Genes, Viral / genetics*
  • Herpesvirus 1, Cercopithecine / genetics*
  • Molecular Sequence Data
  • Open Reading Frames / genetics
  • Sequence Homology, Nucleic Acid
  • Simplexvirus / genetics
  • Viral Proteins / genetics*

Substances

  • Viral Proteins