Autoantibodies to leucocyte antigens in hydralazine-associated nephritis

J Intern Med. 1992 Jan;231(1):37-42. doi: 10.1111/j.1365-2796.1992.tb00496.x.


Clinical and laboratory findings and drug history were studied in 17 patients with suspected hydralazine-associated nephritis, five of whom only had renal disease, while twelve also had extrarenal manifestations. Renal biopsies revealed extracapillary proliferative or focal segmental proliferative glomerulonephritis in 10 patients, and tubulo-interstitial nephritis in five patients. Antinuclear antibody (ANA) was found in 16 patients, but none of the 14 patients tested had antibodies to DNA. Tests for antibodies to myeloperoxidase (anti-MPO) and antibodies to neutrophil cytoplasm antigen (ANCA) were performed by ELISA. Twelve of the 14 patients tested had anti-MPO; five of these 14 patients had ANCA, while one had borderline levels. These findings suggest that hydralazine facilitates the induction of a systemic disease with multiple autoantibody production.

MeSH terms

  • Antibodies, Antinuclear / analysis*
  • Female
  • Glomerulosclerosis, Focal Segmental / chemically induced
  • Glomerulosclerosis, Focal Segmental / immunology*
  • HLA Antigens / immunology*
  • Humans
  • Hydralazine / adverse effects*
  • Male
  • Middle Aged
  • Nephritis, Interstitial / chemically induced
  • Nephritis, Interstitial / immunology*
  • Neutrophils / immunology
  • Peroxidase / immunology


  • Antibodies, Antinuclear
  • HLA Antigens
  • Hydralazine
  • Peroxidase