Sequence alignment of the G-protein coupled receptor superfamily

DNA Cell Biol. 1992 Jan-Feb;11(1):1-20. doi: 10.1089/dna.1992.11.1.


The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for understanding the evolution of these genes. We have compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins*
  • Humans
  • Molecular Sequence Data
  • Multigene Family*
  • Receptors, Cell Surface*
  • Sequence Alignment*


  • Receptors, Cell Surface
  • GTP-Binding Proteins