Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate

Neuron. 1992 Feb;8(2):267-74. doi: 10.1016/0896-6273(92)90293-m.


The presence and primary structure of a novel subunit of the mouse glutamate receptor channel, designated as gamma 2, have been revealed by cloning and sequencing the cDNA. The gamma 2 subunit has structural characteristics common to the neurotransmitter-gated ion channel family and shares a high amino acid sequence identity with the rat KA-1 subunit, thus constituting the gamma subfamily of the glutamate receptor channel. Expression of the gamma 2 subunit together with the beta 2 subunit in Xenopus oocytes yields functional glutamate receptor channels selective for kainate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA / genetics
  • DNA / isolation & purification
  • Female
  • Gene Expression / genetics*
  • Kainic Acid / metabolism*
  • Macromolecular Substances
  • Mice
  • Molecular Sequence Data
  • Oocytes / metabolism
  • Oocytes / physiology
  • Oocytes / ultrastructure
  • Receptors, Glutamate
  • Receptors, Neurotransmitter / chemistry
  • Receptors, Neurotransmitter / genetics*
  • Sequence Homology, Nucleic Acid
  • Xenopus laevis


  • Macromolecular Substances
  • Receptors, Glutamate
  • Receptors, Neurotransmitter
  • DNA
  • Kainic Acid

Associated data

  • GENBANK/D01273