Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41

J Gen Virol. 1992 Feb:73 ( Pt 2):467-70. doi: 10.1099/0022-1317-73-2-467.

Abstract

The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Western
  • Humans
  • Molecular Sequence Data
  • Peptide Fragments / chemistry
  • Peptide Fragments / genetics
  • Phosphoproteins / analysis
  • Phosphoproteins / chemistry
  • Phosphoproteins / genetics
  • Phosphorylation
  • Precipitin Tests
  • Protein Biosynthesis
  • RNA, Messenger / metabolism
  • Simplexvirus / chemistry*
  • Simplexvirus / genetics
  • Vero Cells
  • Viral Proteins / analysis*
  • Viral Proteins / chemistry
  • Viral Proteins / genetics
  • Virion / chemistry*
  • Virion / genetics

Substances

  • Peptide Fragments
  • Phosphoproteins
  • RNA, Messenger
  • Viral Proteins
  • herpes simplex virus type 2 protein UL41