Abstract
The virion-induced host shutoff product of the herpes simplex virus UL41 gene is required for shutoff of host translation and degradation of cellular mRNAs. We employed a rabbit antipeptide antiserum to identify a 58K UL41-related phosphoprotein in infected cells. We also provide evidence that this protein is a component of the virus particle, consistent with its role in virion-induced shutoff.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Blotting, Western
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Humans
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Molecular Sequence Data
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Peptide Fragments / chemistry
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Peptide Fragments / genetics
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Phosphoproteins / analysis
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Phosphoproteins / chemistry
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Phosphoproteins / genetics
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Phosphorylation
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Precipitin Tests
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Protein Biosynthesis
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RNA, Messenger / metabolism
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Simplexvirus / chemistry*
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Simplexvirus / genetics
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Vero Cells
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Viral Proteins / analysis*
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Viral Proteins / chemistry
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Viral Proteins / genetics
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Virion / chemistry*
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Virion / genetics
Substances
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Peptide Fragments
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Phosphoproteins
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RNA, Messenger
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Viral Proteins
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herpes simplex virus type 2 protein UL41