Molecular cloning and characterization of a novel rat activin receptor

Biochem Biophys Res Commun. 1992 Mar 16;183(2):672-9. doi: 10.1016/0006-291x(92)90535-s.

Abstract

We report the isolation of a full-length rat cDNA for a new activin receptor. The deduced amino acid sequence of this receptor shows 67 percent overall identity with that of a previously identified mouse activin receptor. As predicted for the mouse activin receptor, the amino acid sequence of the rat receptor is consistent with a polypeptide containing an extracellular ligand binding domain, a hydrophobic transmembrane domain, and a serine/threonine kinase intracellular domain. In an expression assay, this new receptor was found to bind I125 radiolabeled activin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activin Receptors
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cells, Cultured
  • Cloning, Molecular
  • Molecular Sequence Data
  • Multigene Family / genetics*
  • Polymerase Chain Reaction
  • Protein Kinases / genetics*
  • Receptors, Cell Surface / genetics*
  • Recombinant Proteins / biosynthesis*
  • Sequence Homology, Nucleic Acid

Substances

  • Receptors, Cell Surface
  • Recombinant Proteins
  • Protein Kinases
  • Activin Receptors