Arylguanidine and arylbiguanide binding at 5-HT3 serotonin receptors: a QSAR study

Bioorg Med Chem. 2003 Oct 1;11(20):4449-54. doi: 10.1016/s0968-0896(03)00488-7.


For a series of monosubstituted arylguanidines, 5-HT3 receptor affinity was found generally related to the electron withdrawing nature of the substituent at the aryl 3-position and the lipophilicity of the 4-position substituent. A broader examination of 35 arylguanidines and arylbiguanides revealed that affinity could be described by molecular polarizability, a Chi index term (8chiP), and the sum of all (-Cl) E-State values (SsCl) in the molecule.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electrons
  • Guanidines / chemistry*
  • Guanidines / pharmacology
  • Humans
  • Ligands
  • Protein Binding
  • Quantitative Structure-Activity Relationship*
  • Radioligand Assay
  • Serotonin 5-HT3 Receptor Antagonists*
  • Serotonin Antagonists / chemistry
  • Serotonin Antagonists / pharmacology


  • Guanidines
  • Ligands
  • Serotonin 5-HT3 Receptor Antagonists
  • Serotonin Antagonists