Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion

Gastroenterology. 1992 Apr;102(4 Pt 1):1124-8.


Disruption of the gastric mucosal barrier with resultant increased acid back-diffusion leads to a marked increase in gastric mucosal blood flow (GMBF). This increase in GMBF is blocked by ablation of capsaicin-sensitive sensory neurons. The gastric arterioles are densely innervated by afferent neurons containing vasodilator peptides, calcitonin gene-related peptide (CGRP) being the most potent of these. We investigated (a) whether CGRP is the vasodilator mediator released by acid stimulation of capsaicin-sensitive sensory neurons and (b) whether the resultant hyperemia protects against the acid-induced mucosal injury. When the stomach was perfused with 0.15N HCl plus 15% ethanol, GMBF significantly increased by 70%. This hyperemic response was completely blocked by intra-arterial infusion of human CGRP8-37 (500 pmol/min), a CGRP-receptor antagonist, close to the stomach. With the blockade of the hyperemic response to acid back-diffusion, gross and histological mucosal damage were significantly aggravated. It is concluded that CGRP mediates the gastric hyperemic response to acid back-diffusion and that this gastric hyperemic response is an important protective factor against acid-induced injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcitonin Gene-Related Peptide / pharmacology*
  • Calcitonin Gene-Related Peptide / physiology*
  • Capsaicin / pharmacology
  • Diffusion
  • Ethanol / toxicity
  • Gastric Mucosa / blood supply*
  • Gastric Mucosa / drug effects
  • Hydrochloric Acid / toxicity
  • Male
  • Peptide Fragments / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Calcitonin
  • Receptors, Cell Surface / drug effects*
  • Regional Blood Flow / drug effects


  • Peptide Fragments
  • Receptors, Calcitonin
  • Receptors, Cell Surface
  • calcitonin gene-related peptide (8-37)
  • Ethanol
  • Calcitonin Gene-Related Peptide
  • Hydrochloric Acid
  • Capsaicin