Site of carotid plaque ulceration in relation to direction of blood flow: an angiographic and pathological study

Cerebrovasc Dis. 2003;16(4):369-75. doi: 10.1159/000072559.


Background: Rupture of atherosclerotic plaque is the main cause of acute coronary syndromes and carotid territory ischaemic stroke. Haemodynamic stress is important in early plaque formation and may affect the stability of mature plaques. There is some evidence that macrophage infiltration and plaque rupture tend to localise to the proximal (upstream) part of the plaque where shear stress is highest. However, previous studies have been too small to assess this reliably. We studied the site of ulceration in a large number of carotid plaques.

Methods: We studied angiograms of 3007 symptomatic carotid stenoses, and the pathological appearance of 119 carotid plaques (77 asymptomatic), to identify the presence and position of plaque ulceration.

Results: Angiographic ulceration, which was present in 421 patients (14%), was more likely to be PROXIMAL than DISTAL to the point of maximum stenosis (OR = 16.6, 95% CI = 11.6-26.9, p < 0.001). This trend increased with severity of stenosis (p = 0.002). Pathological examination of the 119 carotid plaques also showed that ulceration was more likely to occur proximal to the point of maximum stenosis (OR = 6.1, 95% CI = 2.8-13.6, p < 0.001).

Conclusions: Ulceration of carotid plaques, visible on angiography or on pathological examination, is seen most often in the proximal (upstream) part where shear stress is highest.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / etiology
  • Brain Ischemia / pathology
  • Carotid Arteries / diagnostic imaging
  • Carotid Arteries / pathology*
  • Carotid Arteries / physiopathology*
  • Carotid Stenosis / diagnostic imaging
  • Carotid Stenosis / pathology*
  • Carotid Stenosis / physiopathology*
  • Cerebral Angiography
  • Cerebrovascular Circulation / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Risk Factors
  • Rupture, Spontaneous / diagnostic imaging
  • Rupture, Spontaneous / etiology
  • Rupture, Spontaneous / pathology
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Shear Strength