A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor

FEBS Lett. 1992 Apr 6;300(3):237-40. doi: 10.1016/0014-5793(92)80853-9.


A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity: sperm receptors Zp2 and Zp3, betaglycan (also called TGF-beta type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-beta receptor complex.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cricetinae
  • Dogs
  • Egg Proteins*
  • Female
  • Glycoproteins / chemistry*
  • Glycoproteins / genetics
  • Humans
  • Male
  • Membrane Glycoproteins*
  • Membrane Proteins / chemistry
  • Mice
  • Molecular Sequence Data
  • Protein Conformation
  • Proteoglycans / chemistry
  • Rats
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / genetics
  • Receptors, Transforming Growth Factor beta
  • Sequence Alignment
  • Sequence Homology, Nucleic Acid
  • Software
  • Spermatozoa / chemistry*
  • Structure-Activity Relationship
  • Transforming Growth Factor beta / chemistry*
  • Transforming Growth Factor beta / genetics
  • Zona Pellucida Glycoproteins


  • Egg Proteins
  • Glycoproteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Proteoglycans
  • Receptors, Cell Surface
  • Receptors, Transforming Growth Factor beta
  • Transforming Growth Factor beta
  • ZP2 protein, human
  • ZP3 protein, human
  • Zona Pellucida Glycoproteins
  • Zp2 protein, mouse
  • Zp3 protein, mouse
  • betaglycan