Curr Opin Cell Biol. 1992 Feb;4(1):43-52. doi: 10.1016/0955-0674(92)90057-j.


The actomyosin contractile-ring mechanism remains the paradigm for cytokinesis after 20 years of experimental testing. Recent evidence suggests that Ca2+ triggers the contraction and that cell-cycle kinases regulate the timing of cytokinesis. New work is required to identify the signals from the mitotic spindle that specify the position of the furrow.

Publication types

  • Review

MeSH terms

  • Actomyosin / physiology*
  • Animals
  • Calcium / physiology
  • Cell Cycle / physiology
  • Cell Division
  • Mitosis / physiology*
  • Myosin-Light-Chain Kinase / physiology
  • Phosphoric Monoester Hydrolases
  • Phosphorylation
  • Spindle Apparatus / physiology


  • Actomyosin
  • Myosin-Light-Chain Kinase
  • Phosphoric Monoester Hydrolases
  • Calcium