Reversible conduction block in human ischemic neuropathy after ergotamine abuse

Muscle Nerve. 1992 Apr;15(4):467-70. doi: 10.1002/mus.880150409.


Conduction block [a significant reduction in compound muscle action potential (CMAP) amplitude after proximal compared to distal stimulation] is often found in demyelinating neuropathies, including inflammatory neuropathies and degenerative neuropathies, such as "liability to pressure neuropathy." There is experimental evidence that a transient conduction block can occur in rats after ischemic lesions of peripheral nerves are induced either by ligation of arterial vessels supplying nerve trunks, or by injection of arachidonic acid into peripheral arterial vessels. Conduction block has also recently been described in cases with necrotizing vasculitis. To date, however, no example of a reversible conduction block has been reported in human ischemic neuropathy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Electromyography
  • Ergotamine / administration & dosage
  • Ergotamine / adverse effects*
  • Ergotamine / therapeutic use
  • Female
  • Humans
  • Ischemia / chemically induced*
  • Migraine Disorders / drug therapy
  • Neural Conduction / drug effects*
  • Peripheral Nerves / blood supply*
  • Peripheral Nervous System Diseases / chemically induced*
  • Peripheral Nervous System Diseases / diagnosis


  • Ergotamine