Comparative analysis of sequence variation in gp116 and gp55 components of glycoprotein B of human cytomegalovirus

Virology. 1992 May;188(1):388-90. doi: 10.1016/0042-6822(92)90771-g.

Abstract

Sequence variation in the gp116 component of cytomegalovirus envelope glycoprotein B was examined in 11 clinical strains and compared with variation in gp55. The peptide variation in gp116 was found to be strongly clustered at codons 27-67, 440-460, and to a lesser extent at codons 181-194, 311-317, and 387-397. Strains adopted one of three to four peptide configurations at these loci, usually consistent with their gp55 sequence configuration. Two instances were observed of a sequence variation arising from recombination within gB. The limited, largely group-specific nature of variation in both gp116 and gp55 facilitates functional and immunologic analyses.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Cytomegalovirus / genetics*
  • Genetic Variation*
  • Molecular Sequence Data
  • Sequence Alignment
  • Viral Envelope Proteins / genetics*

Substances

  • Viral Envelope Proteins
  • glycoprotein B, Simplexvirus

Associated data

  • GENBANK/M60924
  • GENBANK/M60925
  • GENBANK/M60926
  • GENBANK/M60927
  • GENBANK/M60929
  • GENBANK/M60931
  • GENBANK/M60932
  • GENBANK/M60933
  • GENBANK/M60934
  • GENBANK/M85228
  • GENBANK/M85229