A novel reciprocal chromosome translocation t(11;22)(p13;q12) in an intraabdominal desmoplastic small round-cell tumor

Am J Surg Pathol. 1992 Apr;16(4):411-6. doi: 10.1097/00000478-199204000-00010.


We report an intraabdominal desmoplastic small round-cell tumor that contains a novel reciprocal chromosome translocation t(11;22)(p13;q12). The tumor showed a reciprocal chromosome translocation which is different from the (11;22)(q24;q12) translocations seen in Ewing's and other small-cell tumors but affects the same break-point on chromosome 22(q12). This reciprocal chromosome translocation may prove to be a marker for intraabdominal desmoplastic small round-cell tumors.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Neoplasms / diagnosis
  • Abdominal Neoplasms / genetics*
  • Abdominal Neoplasms / pathology
  • Adolescent
  • Biomarkers, Tumor / genetics
  • Carcinoma, Small Cell / diagnosis
  • Carcinoma, Small Cell / genetics*
  • Carcinoma, Small Cell / pathology
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 22*
  • Female
  • Humans
  • Karyotyping
  • Translocation, Genetic / genetics*


  • Biomarkers, Tumor