Molecular cloning and binding properties of the human type II activin receptor

Biochem Biophys Res Commun. 1992 Apr 15;184(1):310-6. doi: 10.1016/0006-291x(92)91194-u.

Abstract

A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activin Receptors
  • Activins
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Gene Library
  • Humans
  • Inhibins / metabolism*
  • Kinetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Molecular Sequence Data
  • Radioligand Assay
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism*
  • Recombinant Proteins / metabolism
  • Restriction Mapping
  • Transfection

Substances

  • Receptors, Cell Surface
  • Recombinant Proteins
  • Activins
  • Inhibins
  • Activin Receptors

Associated data

  • GENBANK/M93415
  • GENBANK/M97581
  • GENBANK/M97582
  • GENBANK/M97583
  • GENBANK/M97584
  • GENBANK/M97585
  • GENBANK/M97586
  • GENBANK/M97587
  • GENBANK/M97588
  • GENBANK/M97589