gamma-Aminobutyric acid A or C receptor? gamma-Aminobutyric acid rho 1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive gamma-aminobutyric acid responses in Xenopus oocytes

Mol Pharmacol. 1992 Apr;41(4):683-7.

Abstract

Xenopus oocyte expression of the recently cloned gamma-aminobutyric acid (GABA) rho 1 receptor subunit cDNA yields a pharmacologic profile characteristic of the GABAc responses described by Johnston [Benzodiazepine/GABA Receptors and Chloride Channels. Receptor Biochemistry and Methodology (R. W. Olsen and J. C. Venter, eds), Vol. 5. Alan R. Liss, New York, 57-71 (1986)] and the responses to retinal mRNA recently reported in the Xenopus expression system [Proc. Natl. Acad. Sci. USA 88:4318-4322 (1991)]. A rationale for defining GABA rho 1 as forming a GABAc receptor is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Barbiturates / pharmacology*
  • Benzodiazepines / pharmacology*
  • Bicuculline / pharmacology*
  • DNA / genetics
  • Ovum
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / metabolism
  • RNA, Messenger / pharmacology
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / genetics
  • Receptors, GABA-A / metabolism*
  • Xenopus
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Barbiturates
  • RNA, Messenger
  • Receptors, GABA-A
  • Benzodiazepines
  • gamma-Aminobutyric Acid
  • DNA
  • Bicuculline