A retrovirus uses a cationic amino acid transporter as a cell surface receptor

Nutr Rev. 1992 Feb;50(2):47-8. doi: 10.1111/j.1753-4887.1992.tb02512.x.


New studies have indicated that the cell membrane receptor for the ecotropic murine leukemia virus is the classic membrane amino acid transporter y+, the principal transporter of cationic L-acids in mammalian cells. This finding has been hailed as a landmark in cell physiology which may reveal new mechanisms of viral pathogenesis. These studies represent the first amino acid transporter to be cloned, as well as the first example of a virus subverting a transmembrane protein as a receptor.

Publication types

  • Review

MeSH terms

  • Amino Acid Transport Systems
  • Amino Acids / metabolism*
  • Animals
  • Biological Transport
  • Carrier Proteins / metabolism*
  • Leukemia Virus, Murine / metabolism*
  • Receptors, Virus / metabolism*


  • Amino Acid Transport Systems
  • Amino Acids
  • Carrier Proteins
  • Receptors, Virus